2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N8193
    Brassicin 6743-96-0 ≥99.0%
    Brassicin, a natural Flavonoid, possesses radical scavenging activity.
    Brassicin
  • HY-N8206
    Chrysophanol tetraglucoside 120181-08-0
    Chrysophanol tetraglucoside possesses anti-hypolipidemic and antibacterial activities.
    Chrysophanol tetraglucoside
  • HY-N8243
    Coreopsin 499-29-6 99.42%
    Coreopsin is a natural product that can be isolated from Coreopsis tinctoria Nutt. flower. Coreopsin can be used for hypertension and diabetes research.
    Coreopsin
  • HY-N8276
    Ro 3-1314 2012-14-8 ≥99.0%
    Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments.
    Ro 3-1314
  • HY-N8375
    Sieboldin 18777-73-6 98.80%
    Sieboldin is a dihydrochalcone, which inhibits the production of advanced glycation end products (AGE) produced by bovine serum albumins (BSA), has free radical scavenging activity and cytotoxicity in cancer cell lines, and is also used to capture of methylglyoxal (MGO) from Malus baccata.
    Sieboldin
  • HY-N8438
    Methyl tetracosanoate 2442-49-1 98.0%
    Methyl tetracosanoate (Methyl lignocerate) is a fatty acid methyl ester with anti-diabetic activity.
    Methyl tetracosanoate
  • HY-N8490
    Eicosyl ferulate 133882-79-8 98.92%
    Eicosyl ferulate, a phenolic compound, is isolated from the fresh root and stem of Aristolochia kankauensis. Eicosyl ferulate exhibits glucose uptake stimulatory activity.
    Eicosyl ferulate
  • HY-N8517
    Malabaricone B 63335-24-0 99.93%
    Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.
    Malabaricone B
  • HY-N8879
    Wilforol A 167882-66-8 98.64%
    Wilforol A ((-)-Wilforol A), plant metabolite, is a pentacyclic triterpenoid. Wilforol A can be used for the research of various biochemical studies.
    Wilforol A
  • HY-N9329
    Glicoricone 161099-37-2
    Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity.
    Glicoricone
  • HY-N9333
    Wistin 19046-26-5
    Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist.
    Wistin
  • HY-N9351
    Cleistanthin B 30021-77-3 98.19%
    Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo.
    Cleistanthin B
  • HY-N9685
    Digitoxose 527-52-6 98.86%
    Digitoxose (D-(+)-Digitoxose), a natural product, specifically and competitively inhibits glucose-stimulated insulin release from islets in lean and obese mice. Digitoxose can be used in diabetes research.
    Digitoxose
  • HY-NP180
    Progesterone/BSA
    Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes.
    Progesterone/BSA
  • HY-NP205
    Glycated Albumin (Human)
    Glycated Albumin (Human) is an alternative marker for glycemic control. Glycated Albumin (Human) can react with glucose.
    Glycated Albumin (Human)
  • HY-P0262
    Galantide 138579-66-5 98%
    Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM).
    Galantide
  • HY-P1021
    Peptide YY (PYY) (3-36), porcine 126339-09-1 98%
    Peptide YY (PYY) (3-36), porcine is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.
    Peptide YY (PYY) (3-36), porcine
  • HY-P1128
    Galanin (swine) 88813-36-9 98.99%
    Galanin (swine), a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) is a galanin receptor agonist with pKis of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively.
    Galanin (swine)
  • HY-P1143
    [Des-His1,Glu9]-Glucagon amide 110084-95-2 99.32%
    [Des-His1,Glu9]-Glucagon amide is a potent and peptide antagonist of the glucagon receptor, with a pA2 of 7.2. [Des-His1,Glu9]-Glucagon amide is potentially useful in the study of the pathogenesis of diabetes.
    [Des-His1,Glu9]-Glucagon amide
  • HY-P1204
    [Ala17]-MCH 359784-84-2 98.28%
    [Ala17]-MCH, a MCH analogue (HY-P1525A), is a selective ligand for MCHR1 (Ki=0.16 nM) over MCHR2 (Ki=34 nM). [Eu3+ chelate-labeled [Ala17]-MCH shows high affnity for MCHR1 (Kd=0.37 nM) while has little demonstrable binding affnity for MCHR2.
    [Ala17]-MCH
Cat. No. Product Name / Synonyms Application Reactivity